Adrenocortical Steroid Therapy and Pituitary-Adrenocortical Function

Adrenocortical steroid metabolism and adrenal cortical function in liver disease.

The hypothalamo-pituitary-adrenocortical system.

Control of the secretion of ACTH appears to involve several mechanisms. It is dependent upon the release, from neurones in the hypothalamus, of corticotrophin releasing factor, which is probably a complex including CRF-41 and vasopressin. The secretion of the complex is influenced by various central inhibitory and excitatory nervous pathways. The releasing factor is conveyed by the hypophyseal ...

Drugs and Adrenocortical Function

This investigation forms part of a study of the secretory capacity of the rat's adrenal cortex after structural changes have been produced in the gland by the administration of drugs and hormones. The two examples to be discussed are the effects of hexoestrol' and of 'amphenone B' (1, 2-bis (p-aminophenyl)-2 methyl-propanone-1 dihydrochloride). The latter substance, subsequently to be called 'a...

Assessment of adrenocortical function in cases of pituitary tumour.

Short ACTH test in assessing hypothalamic-pituitary-adrenocortical function.

The adrenocortical response to the simple 30-minute ACTH stimulation test was compared with the hypothalamic-pituitary-adrenocortical (HPA) response to insulin-induced hypoglycaemia in 25 patients with various degrees of hypothalamic-pituitary malfunction. The correlations between the increase in plasma cortisol during insulin hypoglycaemia and that during ACTH stimulation (r = 0-66) and betwee...